Gene

fat2

ID

ZDB-GENE-111031-1

Name

FAT atypical cadherin 2

Symbol

fat2 Nomenclature History

Previous Names

fk09f07
wu:fk09f07

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable calcium ion binding activity. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in plasma membrane. Predicted to be active in adherens junction. Is expressed in cerebellum; granule cell; hindbrain; and optic tectum. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 45. Orthologous to human FAT2 (FAT atypical cadherin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Takeuchi et al., 2017

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fat2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spinocerebellar ataxia 45	Alliance	Spinocerebellar ataxia 45	617769

Associated With fat2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020894	Cadherin conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001791	Laminin G domain
Domain	IPR002126	Cadherin-like
Family	IPR039808	Cadherin
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR015919	Cadherin-like superfamily

Domain Details Per Protein

Protein	Length	Cadherin	Cadherin conserved site	Cadherin-like	Cadherin-like superfamily	Concanavalin A-like lectin/glucanase domain superfamily	EGF-like domain	Laminin G domain
UniProtKB:E7FB42 InterPro	4342

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	fat2-201 (1) Ensembl	Ensembl		16,416 nt	Select Tool ZFIN BLAST
ncRNA	fat2-002 (1) Ensembl	Ensembl		629 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations